Clinical pharmacokinetics of systemically administered antimycotics.

@article{Bellmann2007ClinicalPO,
  title={Clinical pharmacokinetics of systemically administered antimycotics.},
  author={Romuald Bellmann},
  journal={Current clinical pharmacology},
  year={2007},
  volume={2 1},
  pages={
          37-58
        }
}
Systemic fungal infections are a major threaten for immunocompromised patients. Beside the antimycotic spectrum, the pharmacokinetic properties of an antifungal drug are crucial for its clinical efficacy. Since patients with systemic mycoses frequently present with a significant co-morbidity, pharmacokinetics under special conditions such as renal insufficiency, renal replacement therapy or impaired liver function have to be considered. Amphotericin B is eliminated unchanged by the liver and… CONTINUE READING
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