Clinical pharmacokinetics of metformin.

  title={Clinical pharmacokinetics of metformin.},
  author={Garry G Graham and Jeroen Punt and Manit Arora and Richard O. Day and Matthew P. Doogue and J K Duong and Timothy John Furlong and Jerry R Greenfield and Louise C Greenup and Carl M. J. Kirkpatrick and John E. Ray and Peter Timmins and Kenneth Mapson Williams},
  journal={Clinical pharmacokinetics},
  volume={50 2},
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean ± SD fractional oral bioavailability (F) of metformin is 55 ± 16%. It is absorbed predominately from the small intestine… CONTINUE READING
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Metformin kinetics in healthy subjects and inpatientswith diabetesmellitus.Br JClin Pharmacol

  • GT Tucker, C Casey, PJ Phillips
  • 1981
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