Clinical pharmacokinetics of lorazepam

@article{Greenblatt1976ClinicalPO,
  title={Clinical pharmacokinetics of lorazepam},
  author={David J Greenblatt and R. T. Schillings and Adrian A. Kyriakopoulos and RichardI. Shader and Samuel F. Sisenwine and John A. Knowles and Hans W. Ruelius},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1976},
  volume={20}
}
Eight healthy male subjects received single 2‐mg oral doses of lorazepam containing 24 uLCi Img of 2‐14C‐lorazepam. Multiple venous blood samples were drawn during the .first 96 hr after the dose, and all urine and stool were collected for 120 hr after dosing. Concentrations of lorazepam and its metabolites in body fluids were determined by appropriate analytic techniques. Following a lag time, lorazepam was absorbed with an apparent first‐order half‐life of 15 min. The peak plasma… 

Clinical Pharmacokinetics of Lorazepam. III. Intravenous Injection. Preliminary Results

Four healthy male volunteers received 5 mg lorazepam as a single intravenous injection. Concentrations of lorazepam and its glucuronide metabolite were determined in multiple venous blood samples

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Six healthy volunteers received single 2- and 4-mg doses of lorazepam by 5-min intravenous infusion, in tablet form by mouth in the fasting state, and by deltoid intramuscular injection in a six-way

Clinical Pharmacokinetics of Lorazepam. IV. Long‐Term Oral Administration

Mean steady-state lorazepam levels were highly correlated with daily dose in mg/kg, but were not related to age, and Lorzepam was not detected in any plasma samples drawn one week after discontinuation of treatment.

Single- and multiple-dose kinetics of oral lorazepam in humans: The predictability of accumulation

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Pharmacokinetics and bioavailability of intravenous and intramuscular lorazepam with an adjunct test of the inattention effect in humans.

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The pharmacokinetics and metabolism of the new benzodiazepine lormetazepam were investigated in five male volunteers using thel4C-abelled drug, finding that the drug was absorbed completely and eliminated almost exclusively by the renal route.

Pharmacokinetics of two lorazepam formulations, oral and sublingual, after multiple doses.

The pharmacokinetic profiles of a sublingual and a conventional oral lorazepam tablet formulation were established following chronic administration to twelve healthy male volunteers, and the observed time to steady-state for both formulations was approximately 3 days, which agrees well with that predicted from previous single dosing studies.

Clinical Pharmacokinetics of Oxazepam and Lorazepam

3-hydroxy benzodiazepine derivatives used as sedatives and anxiolytics and Oral and intramuscular lorazepam are rapidly absorbed, with systemic availability averaging 90 % or more.

Disposition pharmacokinetics of lorazepam in the rabbit.

The disposition pharmacokinetics of the sedative and anxiolytic drug lorazepam were investigated in 8 rabbits in relation to intravenous bolus injection of 0.3 or 0.6 mg of the compound. Lorazepam

Antipyrine Plasma and Urine Metabolite Disposition with Lorazepam Coadministration

Although antipyrine and lorazepam have been individually used in the separate assessment of phase I and phase II liver function, their simultaneous use after a single injection has also been suggested and the plasma total-body clearances of the two agents were not different when they were administered alone or in combination.
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