Clinical pharmacokinetics of lorazepam

@article{Greenblatt1976ClinicalPO,
  title={Clinical pharmacokinetics of lorazepam},
  author={D. Greenblatt and R. Schillings and A. Kyriakopoulos and R. Shader and S. Sisenwine and J. Knowles and H. W. Ruelius},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1976},
  volume={20}
}
Eight healthy male subjects received single 2‐mg oral doses of lorazepam containing 24 uLCi Img of 2‐14C‐lorazepam. Multiple venous blood samples were drawn during the .first 96 hr after the dose, and all urine and stool were collected for 120 hr after dosing. Concentrations of lorazepam and its metabolites in body fluids were determined by appropriate analytic techniques. Following a lag time, lorazepam was absorbed with an apparent first‐order half‐life of 15 min. The peak plasma… Expand
Clinical Pharmacokinetics of Lorazepam. III. Intravenous Injection. Preliminary Results
Four healthy male volunteers received 5 mg lorazepam as a single intravenous injection. Concentrations of lorazepam and its glucuronide metabolite were determined in multiple venous blood samplesExpand
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