Clinical pharmacokinetics of lignocaine.

  title={Clinical pharmacokinetics of lignocaine.},
  author={Neal L. Benowitz and W. Meister},
  journal={Clinical pharmacokinetics},
  volume={3 3},
Lignocaine is widely used as a local anaesthetic and antiarrhythmic drug. It is commonly administered to patients with acute myocardial infarction as prophylaxis for ventricular fibrillation, although its efficacy in preventing primary ventricular fibrillation is still debated. Toxicity, sometimes with serious clinical consequence, is not uncommom and is usually related to overdosage. Blood lignocaine concentrations correlate roughly with antiarrhythmic and toxic effects and might be useful as… CONTINUE READING

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