Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease

  title={Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease},
  author={Pamela Braithwaite and Michael S. Roberts and Rodriguez Allan and Thomas R. Watson},
  journal={European Journal of Clinical Pharmacology},
The plasma concentrations of mebendazole and its metabolites have been monitored in twelve patients after receiving a 10 mg/kg dose for cystic hydatid disease. The mebendazole plasma concentration-time profiles differed considerably between patients; elimination half-lives ranged from 2.8–9.0 h, time to peak plasma concentration after dosing ranged from 1.5–7.25 h and peak plasma concentrations ranged from 17.5 to 500 ng/ml. The mean peak plasma concentration of mebendazole after an initial… CONTINUE READING
16 Citations
52 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Vertebral hydatidosis : Radiotogi - cal appearance

  • PA Braithwaite, RF Lees
  • Aust NZ J Surg
  • 1981

Anthelmintic activity of mebendazole on larval stages of Echinococcusgranulosus in mice

  • OF Vanparijs, L Hermans, D Thienpont
  • Janssen Res Prod Inf Service N 11087 Van…
  • 1980

Clinical results obtained in the treatment of hydatid disease with mebendazole in Tasmania. Proceedings, workshop on chemotherapy of larval echinococcosis

  • PA Braithwaite
  • 1980
2 Excerpts

Experimental chemotherapy of larval Echinococcosis in laboratory Animals

  • J Eckert
  • Workshop on chemotherapy of larval echinococcosis…
  • 1980

Similar Papers

Loading similar papers…