Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.

@article{Twelves1992ClinicalPO,
  title={Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.},
  author={Christopher J. Twelves and Nicola A. Dobbs and Yvonne L. Michael and L. A. Summers and W. J. Gregory and Peter G. Harper and Robert D. Rubens and Michael A. Richards},
  journal={British Journal of Cancer},
  year={1992},
  volume={66},
  pages={765 - 769}
}
The influence of liver biochemistry tests on epirubicin pharmacokinetics has been investigated in 52 women with advanced breast cancer, 27 of whom had radiologically proven liver metastases. Patients received epirubicin 12.5-120 mg m-2 given as an i.v. bolus. Epirubicin levels were measured by HPLC following the first cycle of treatment. Epirubicin elimination, expressed as clearance (dose/AUC), in the 22 patients with normal AST and bilirubin was compared with that of 30 patients with a raised… CONTINUE READING
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