Clinical pharmacokinetics of diacerein.

  title={Clinical pharmacokinetics of diacerein.},
  author={Patrick Nicolas and Michel Tod and Christophe Padoin and Olivier Petitjean},
  journal={Clinical pharmacokinetics},
  volume={35 5},
Diacerein is a drug for the treatment of patients with osteoarthritis. This drug is administered orally as 50 mg twice daily. Diacerein is entirely converted into rhein before reaching the systemic circulation. Rhein itself is either eliminated by the renal route (20%) or conjugated in the liver to rhein glucuronide (60%) and rhein sulfate (20%); these metabolites are mainly eliminated by the kidney. The pharmacokinetics characteristics of diacerein are about the same in young healthy… CONTINUE READING


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