Clinical pharmacokinetics of cimetidine.

  title={Clinical pharmacokinetics of cimetidine.},
  author={Andrew Alexander Somogyi and Roland Gugler},
  journal={Clinical pharmacokinetics},
  volume={8 6},
Cimetidine is the first histamine H2-receptor antagonist with wide clinical application. It is a weak base and a highly water-soluble compound which can be measured in biological fluids by a number of high-pressure liquid chromatographic methods. Following intravenous administration, the plasma concentration profile follows multicompartmental characteristics. The total systemic clearance is high (500 to 600 ml/min) and is mainly determined by renal clearance. The volume of distribution (Vd beta… CONTINUE READING