Clinical pharmacokinetics of antithyroid drugs.

  title={Clinical pharmacokinetics of antithyroid drugs.},
  author={Jens Peter Konnerup Kampmann and J. M. Hansen},
  journal={Clinical pharmacokinetics},
  volume={6 6},
Organic antithyroid drugs used today include propylthiouracil and the mercaptoimidazolines, carbimazole and methimazole. They can be measured with accuracy and in small quantities in serum by gas-liquid chromatography, high performance liquid chromatography and radio-immunoassay. Bioavailability of these drugs varies from 80 to 95%. During absorption carbimazole, which itself is inactive, is completely converted to methimazole. The total volume of distribution is about 40L for methimazole and… CONTINUE READING
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