Clinical pharmacokinetics of adriamycin in hepatoma patients with cirrhosis.

@article{Chan1980ClinicalPO,
  title={Clinical pharmacokinetics of adriamycin in hepatoma patients with cirrhosis.},
  author={Kenneth K Y Chan and Rowan Chlebowski and M J Tong and H. S. Chen and Joseph F. Gross and Joseph R. Bateman},
  journal={Cancer research},
  year={1980},
  volume={40 4},
  pages={1263-8}
}
patients with liver dysfunction, plasma AD levels have been found to be elevated and prolonged (5). This elevation and prolongation of plasma AD levels was found to correlate with the elevation of bilinubin, and the ob servation has led to an empirical index for dose adjustments on the basis of liven function as determined by bilirubin and transaminase levels (2). The phanmacokinetic studies used to develop this index involved primarily patients with cancer met astatic to the liver. Since AD is… CONTINUE READING