Clinical pharmacokinetics and pharmacology of trimetrexate.

  title={Clinical pharmacokinetics and pharmacology of trimetrexate.},
  author={John Marshall and Robert J Delap},
  journal={Clinical pharmacokinetics},
  volume={26 3},
Trimetrexate represents one of a number of new antimetabolites that have been studied in malignant, rheumatological and infectious disease. Methotrexate, the classical antifolate agent, is active in a broad spectrum of clinical settings, but its use is limited ny pre-existing or acquired cellular resistance. Trimetrexate is an agent that does not require uptake by the folate carrier transport system, a major mechanism of cellular resistance both in vitro and in vivo. Both dihydrofolate… CONTINUE READING


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