Clinical pharmacokinetics and pharmacodynamics of insulin aspart.

  title={Clinical pharmacokinetics and pharmacodynamics of insulin aspart.},
  author={Anders Lindholm and Lisbeth Vesterg{\aa}rd Jacobsen},
  journal={Clinical pharmacokinetics},
  volume={40 9},
Insulin aspart is a novel rapid-acting insulin analogue with improved subcutaneous absorption properties when compared with soluble human insulin. Pharmacokinetic studies show an absorption profile with a time to reach peak concentration (t(max)) about half that of human insulin, a peak plasma drug concentration (Cmax) approximately twice as high and shorter residence time. The potency and bioavailability of insulin aspart are similar to those of human insulin. The pharmacokinetics of insulin… CONTINUE READING