Clinical pharmacokinetic considerations in the control of oral anticoagulant therapy.

@article{Shetty1989ClinicalPC,
  title={Clinical pharmacokinetic considerations in the control of oral anticoagulant therapy.},
  author={Harsha M. Shetty and A G Fennerty and Philip A Routledge},
  journal={Clinical pharmacokinetics},
  year={1989},
  volume={16 4},
  pages={238-53}
}
Aspects of the pharmacokinetics of warfarin that are clinically relevant are reviewed here. Since warfarin is normally completely absorbed, resistance to treatment due to impaired absorption is unusual, even in severe short bowel syndrome. Warfarin is highly albumin-bound; thus, hypoalbuminaemic states result in an increased free fraction of the drug and a decreased half-life but, as might be expected, there is no evidence of altered response at steady-state. Warfarin is completely metabolised… CONTINUE READING