Clinical pharmacokinetic considerations in the elderly. An update.

  title={Clinical pharmacokinetic considerations in the elderly. An update.},
  author={Sheila Dawling and Peter Crome},
  journal={Clinical pharmacokinetics},
  volume={33 4},
There are numerous studies of drug handling in the elderly, but it is difficult to assess the significance of changes seen in vitro, or after single-dose administration, because they are often compensated by other mechanisms at steady-state. However, a knowledge of these studies is important as the results alert the investigator to possible treatment problems. The high incidence of adverse drug reaction in the elderly population leaves no doubt that improvements in therapy are needed. Research… CONTINUE READING