Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.

  title={Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.},
  author={Miguel Mart{\'i}n and Teri E. Klein and Betty J Dong and Munir Pirmohamed and David W. Haas and Deanna L. Kroetz},
  journal={Clinical pharmacology and therapeutics},
  volume={91 4},
Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B*57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects ~6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at for… CONTINUE READING
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