Clinical perspectives on pulmonary systemic and macromolecular delivery.

@article{Scheuch2006ClinicalPO,
  title={Clinical perspectives on pulmonary systemic and macromolecular delivery.},
  author={Gerhard Scheuch and Martin J. Kohlhaeufl and Peter Brand and Ruediger Siekmeier},
  journal={Advanced drug delivery reviews},
  year={2006},
  volume={58 9-10},
  pages={
          996-1008
        }
}
The large epithelial surface area, the high organ vascularization, the thin nature of the alveolar epithelium and the immense capacity for solute exchange are factors that led the lung to serve as an ideal administration route for the application of drugs for treatment of systemic disorders. However, the deposition behaviour of aerosol particles in the respiratory tract depends on a number of physical (e.g. properties of the particle), chemical (e.g. properties of the drug) and physiological (e… Expand
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