Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone
@article{Wood2010ClinicalPO, title={Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone}, author={David M. Wood and Shaun L Greene and Paul I Dargan}, journal={Emergency Medicine Journal}, year={2010}, volume={28}, pages={280 - 282} }
Background There is evidence of increasing use of the synthetic cathinone mephedrone (4-methylmethcathinone), particularly amongst clubbers. However, there have only two single case reports of mephedrone toxicity. The aim of this study is to report the pattern of clinical toxicity seen with mephedrone use. Case Series We describe 15 patients who presented to our Emergency Department following self-reported mephedrone use. Significant clinical features seen included agitation in 53.3…
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References
SHOWING 1-10 OF 35 REFERENCES
Recreational Use of Mephedrone (4-Methylmethcathinone, 4-MMC) with Associated Sympathomimetic Toxicity
- MedicineJournal of Medical Toxicology
- 2010
This is the first case of isolated 4-MMC toxicity, with confirmatory analytical findings, and it is important that clinical toxicologists and emergency physicians work together to ensure a better understanding of the toxicity of novel/emerging drugs such as 4-methcathinone.
Toxic effects of BZP-based herbal party pills in humans: a prospective study in Christchurch, New Zealand.
- MedicineThe New Zealand medical journal
- 2005
The results of this study indicate that BZP can cause unpredictable and serious toxicity in some individuals, and should be carefully considered in any discussion on the legal status of piperazine-based party pills.
A review of the neuropharmacological properties of khat
- MedicineProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2008
Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition
- Political Science
- 2010
Significant changes in British recreational drug use were seen throughout 2009, with the emergence and rapid growth in the availability and use of substituted cathinones or ‘M‐Cats’ (most notably…
Mechanism of action of cathinone: the active ingredient of khat (Catha edulis).
- Biology, PsychologyEast African medical journal
- 2000
The experimental work shows that cathinone is a liable substance, structually related to Amphetamine, and similarly to amphetamine, increases the levels of dopamine in the brain by acting on the cathecholaminergic synaspes, Hence the psychostimulant effect of khat can be accounted for by the mechanism of cathin one, which is considered to be its main active ingredient.
Khat: an amphetamine-like plant material.
- BiologyBulletin of the World Health Organization
- 1984
It has been shown that (-)-cathinone acts by the same mechanism as (+)-amphetamine, i.e., by inducing release at physiological catecholamine storage sites, indicating that khat must be considered an amphetamine-like material.
Five-year trends in patterns of drug use among people who use stimulants in dance contexts in the United Kingdom.
- MedicineAddiction
- 2005
This purposively sampled population study has yielded time trend data broadly consistent with other indicators, where they exist, and also has demonstrable potential to identify new drug trends.
Improvement in the management of acutely poisoned patients using an electronic database, prospective audit and targeted educational intervention
- MedicinePostgraduate Medical Journal
- 2008
An electronic clinical toxicology database to prospectively collect all aspects of clinical information on poisoned-patient presentations enabled design and implementation of targeted educational interventions to address shortfalls in patient management, and led to significant improvements in the clinical care of acutely poisoned patients presenting to the ED.