Clinical pathology: preanalytical variation in preclinical safety assessment studies--effect on predictive value of analyte tests.

Abstract

Significant differences in concentrations of analytes in samples may be introduced before samples enter analyzers. These differences are known as preanalytical variation and are part of the overall variation in analytical data. Preanalytical variation is caused by factors that operate during animal preparation prior to sampling, sample collection, sample… (More)

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