Clinical pancreatic islet transplantation

@article{Shapiro2017ClinicalPI,
  title={Clinical pancreatic islet transplantation},
  author={A M James Shapiro and Marta Pokrywczyńska and Camillo Ricordi},
  journal={Nature Reviews Endocrinology},
  year={2017},
  volume={13},
  pages={268-277}
}
Clinical pancreatic islet transplantation can be considered one of the safest and least invasive transplant procedures. Remarkable progress has occurred in both the technical aspects of islet cell processing and the outcomes of clinical islet transplantation. With >1,500 patients treated since 2000, this therapeutic strategy has moved from a curiosity to a realistic treatment option for selected patients with type 1 diabetes mellitus (that is, those with hypoglycaemia unawareness, severe… 
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387 Citations
Highly Influential Citations
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92
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387 Citations

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Clinical islet transplantation: is the future finally now?
TLDR
Implementation of novel immunosuppression, antiinflammatories, first-in-human stem cell and extrahepatic transplant site trials into clinical investigation has positioned islet transplantation to become the mainstay treatment for all T1DM patients in the near future.
Treating diabetes with islet cell transplantation: Lessons from the Edmonton experience
Current state and future evolution of pancreatic islet transplantation
TLDR
Good therapeutic effects of islet transplantation as a result of accurate blood glucose level–reactive insulin secretion, which cannot be reproduced by current drug therapy, have been confirmed.
Pancreatectomy, Islet Cell Transplantation, and Nutrition Considerations.
TLDR
The benefits of performing the clinical islet transplantation on a subgroup of patients with type 1 diabetes and pancreatitis are highlighted and new data are summarized that identify the pivotal role of nutrition support as a critical intervention in their management.
Islet Transplantation Alone Versus Solitary Pancreas Transplantation: an Outcome-Driven Choice?
TLDR
Both outcome-driven and non-outcome-driven criteria are considered in the conclusions, in an attempt to streamline indications for islet-alone or pancreas-alone transplantation.
Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus
TLDR
Clinical translation of promising experimental findings that serve to lay the foundation for CO in islet transplantation to replace the role of insulin therapy, and thus acting as a cure for type 1 diabetes mellitus and preventing long-term diabetic complications are discussed.
Update on islet cell transplantation
TLDR
This review provides an update on islet cell transplantation, focusing on recent clinical experience, ongoing research, and future challenges, and demonstrates advances in terms of long-term glycemic control, improved insulin independence rates, and novel approaches to eliminate chronic immunosuppression requirements after isletcell transplantation.
Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human
TLDR
The causes leading to diabetes are analyzed and the immunological mechanisms responsible for rejection between mouse and human are compared and a better understanding of the experimental mouse models should facilitate translation to human clinical application.
Transplantation: Pancreatic and Islet Cells
Islet vs pancreas transplantation in nonuremic patients with type 1 diabetes
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