Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy.

  title={Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy.},
  author={Patrick Vermersch and Ludwig Kappos and Ralf Gold and J. Foley and Tomas Olsson and Diego Cadavid and Carmen Bozic and Sandra Richman},
  volume={76 20},
OBJECTIVE Natalizumab, a therapy for multiple sclerosis (MS), has been associated with progressive multifocal leukoencephalopathy (PML), a rare opportunistic infection of the CNS associated with the JC virus. We assessed clinical outcomes and identified variables associated with survival in 35 patients with natalizumab-associated PML. METHODS Physicians provided Karnofsky scores and narrative descriptions of clinical status. Data were supplemented by the natalizumab global safety database… CONTINUE READING


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