Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature

@article{Ciccone2016ClinicalOO,
  title={Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature},
  author={Marcia A. Ciccone and Asaf Maoz and Jennifer K. Casabar and Hiroko Machida and Seiji Mabuchi and Koji Matsuo},
  journal={Expert Opinion on Investigational Drugs},
  year={2016},
  volume={25},
  pages={781 - 796}
}
ABSTRACT Introduction: While serine-threonine kinases (STK) are attractive therapeutic targets in epithelial ovarian cancer, clinical outcomes of STK inhibitors in the management of recurrent disease have not been completely described. Areas covered: A systematic literature review of published clinical studies on STK inhibitors targeting mTOR, MAPK, and aurora kinase pathways in recurrent epithelial ovarian cancer was conducted, revealing 18 clinical trials (497 patients). Pooled analyses were… 
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