Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.

@article{Devitt2011ClinicalOA,
  title={Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.},
  author={Bianca Devitt and W. William Liu and Renato Salemi and R. T. Wolfe and John Arthur Kelly and C Y Tzen and Alexander Dobrovic and Grant Mcarthur},
  journal={Pigment cell & melanoma research},
  year={2011},
  volume={24 4},
  pages={
          666-72
        }
}
The effect of NRAS mutations on the pathological features and clinical outcomes in patients with cutaneous melanoma was compared with that of tumors containing BRAF(V600E) mutations and tumors wild type for both (WT). Clinical outcome data were obtained from a prospective cohort of 249 patients. Mutations involving NRAS and BRAF(V600E) were detected by PCR and were sequence verified. Cox proportional hazards regression was performed to relate NRAS and BRAF mutations to clinical outcome. Seventy… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 95 CITATIONS, ESTIMATED 46% COVERAGE

Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies.

  • Cancer immunology research
  • 2015
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nras in melanoma: targeting the undruggable target.

  • Critical reviews in oncology/hematology
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Drug targets and predictive biomarkers in the management of metastatic melanoma

  • Pharmacogenomics and personalized medicine
  • 2012
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Targeting NRAS in melanoma.

VIEW 4 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED

Targeting the ERK Signaling Pathway in Melanoma

  • International journal of molecular sciences
  • 2019
VIEW 2 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019