Clinical methods in psychiatric genetics: I. Robustness of genetic marker investigative strategies

@article{Gershon1986ClinicalMI,
  title={Clinical methods in psychiatric genetics: I. Robustness of genetic marker investigative strategies},
  author={Elliot S. Gershon and Lynn R Goldin},
  journal={Acta Psychiatrica Scandinavica},
  year={1986},
  volume={74}
}
Abstract— Population stratification, secondary effects of illness or treatment, biological heterogeneity of a clinical syndrome, or complex biology underlying a syndrome (where only one component is measured) are conditions which may obscure the association of a genetic risk factor with a clinical syndrome. We consider several investigative strategies under each of these conditions. Only segregation‐based paradigms are robust to genetic heterogeneity and population stratification. But secondary… 
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