Clinical manifestations and BTK gene defect in 4 unrelated Taiwanese families with Bruton's disease.


BACKGROUND AND OBJECTIVE X-linked agammaglobulinemia (XLA, also called Bruton's disease) is is an X-linked recessive disorder characterized by recurrent bacterial infections, usually occurring in the first few years of life. Here, we report the results of a BTK gene mutation screening study that was performed in Taiwanese families with the BTK gene defect… (More)