Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone.

@article{Brooke1987ClinicalIO,
  title={Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone.},
  author={Michael H Brooke and Gerald M. Fenichel and Robert Griggs and Jerry R. Mendell and Richard T. Moxley and J. Philip Miller and Karl-Heinz Kaiser and James M. Florence and Shree Pandya and Luciano Signore},
  journal={Archives of neurology},
  year={1987},
  volume={44 8},
  pages={812-7}
}
We investigated the effect of high-dose prednisone therapy in 33 boys with Duchenne muscular dystrophy. The drug was given daily in doses of 1.5 mg/kg of body weight (to a maximum of 80 mg) for six months. Muscle strength, joint contractures, timed functional tests, functional ability, and pulmonary function were measured at the beginning and end of the treatment period. The trial was designed using natural history controls, and the power of the study was 0.80 to detect a slowing of 50% in the… CONTINUE READING

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