Clinical insights into the pathogenesis of primary pulmonary hypertension.

@article{Rich1998ClinicalII,
  title={Clinical insights into the pathogenesis of primary pulmonary hypertension.},
  author={Stuart Rich},
  journal={Chest},
  year={1998},
  volume={114 3 Suppl},
  pages={237S-241S}
}
Because of the lack of adequate animal models, much of our knowledge of the pathogenesis of primary pulmonary hypertension has come from clinical experiences. The clinical response to vasodilators, prostenoids, and anticoagulants as treatments appear to correlate with the pathologic changes of medial hypertrophy, intimal proliferation, and thrombosis. Endothelial dysfunction, as a primary abnormality in primary pulmonary hypertension, provides an explanation for the pathologic and clinical… CONTINUE READING