Clinical information on serum IGFBP-3 levels and IGFBP-3 proteolytic activity in childhood.

@article{Hasegawa1995ClinicalIO,
  title={Clinical information on serum IGFBP-3 levels and IGFBP-3 proteolytic activity in childhood.},
  author={Yukihiro Hasegawa and Tomonobu Hasegawa and Kenji Fujii and H Konii and Makoto Anzo and Taiji Aso and Shuji Kotoh and Yutaka Tsuchiya},
  journal={Progress in growth factor research},
  year={1995},
  volume={6 2-4},
  pages={457-63}
}
In this review paper, three pieces of clinical information in childhood are presented: (1) IGFBP-3 may replace GH provocation tests in the diagnosis of GH deficiency (GHD); (2) IGFBP-3 levels are regulated by IGF-I levels in a short period, and (3) ratio of free IGF-I to total IGF-I is high in serum of early infancy, similarly to serum of pregnancy, only partially owing to the presence of IGFBP-3 proteolytic activity. Each paper will be published soon.