Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition.

  title={Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition.},
  author={A Myron Johnson and Giampaolo Merlini and J. C. Sheldon and Kiyoshi Ichihara},
  journal={Clinical chemistry and laboratory medicine},
  volume={45 3},
A large number of circumstances are associated with reduced serum concentrations of transthyretin (TTR), or prealbumin. The most common of these is the acute phase response, which may be due to inflammation, malignancy, trauma, or many other disorders. Some studies have shown a decrease in hospital stay with nutritional therapy based on TTR concentrations, but many recent studies have shown that concentrations of albumin, transferrin, and transthyretin correlate with severity of the underlying… CONTINUE READING
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