Clinical improvement and survival in breast cancer leptomeningeal metastasis correlate with the cytologic response to intrathecal chemotherapy

@article{Clatot2009ClinicalIA,
  title={Clinical improvement and survival in breast cancer leptomeningeal metastasis correlate with the cytologic response to intrathecal chemotherapy},
  author={Florian Clatot and G{\'e}raldine Philippin-Lauridant and Matthieu-John Ouvrier and Tony Nakry and Sophie Laberge-Le-Couteulx and C{\'e}cile Guillemet and Corinne Veyret and Emmanuel Blot},
  journal={Journal of Neuro-Oncology},
  year={2009},
  volume={95},
  pages={421-426}
}
Leptomeningeal meningitis occurs in approximately 5% of metastatic breast cancers, and there is no standard treatment for this complication. We retrospectively analyzed the clinical data and cerebrospinal fluid of 24 patients treated with high-dose intrathecal methotrexate for breast cancer leptomeningeal meningitis (BLM). Cytologic response (CSF cytology without neoplastic cells after treatment) was observed in 11 patients (46%) and related to survival (P = 0.005). In addition, clinical… CONTINUE READING