Clinical importance of the renin-angiotensin system in chronic heart failure: double blind comparison of captopril and prazosin.

@article{Bayliss1985ClinicalIO,
  title={Clinical importance of the renin-angiotensin system in chronic heart failure: double blind comparison of captopril and prazosin.},
  author={John R. Bayliss and Michael S. Norell and Rudolph CANEPA-ANSON and Christopher S. Reid and P Poole-Wilson and George C. Sutton},
  journal={British medical journal},
  year={1985},
  volume={290 6485},
  pages={
          1861-5
        }
}
Nineteen patients with chronic heart failure participated in a double blind crossover trial of captopril and prazosin--two drugs with differing neuroendocrine effects--to determine whether neuroendocrine changes could explain clinical and haemodynamic responses to treatment. Patients were assessed before and after acute and long term (four weeks') treatment with each drug given in random order. Sixteen patients completed the study. During captopril haemodynamic improvement was maintained by… CONTINUE READING

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