Proteomic analysis of cytochromes P450: a mass spectrometry approach.
- BiologyBiochemical Society transactions
MS provides a convenient method for the identification and quantification of CYP enzymes, and in the present paper the current state of the technology for such an analysis is reviewed.
Cytochrome P450 Polymorphisms
This chapter summarizes the functional, clinical, and toxicological relevance of human P450 genetic polymorphism, which affects all drug-metabolizing CYPs, but to a very different extent.
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction
- BiologyBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
An introduction to a few of the many aspects of P450 research relating to humans is provided to introduce additional ways of thinking about metabolism and applications to topics widely taught in undergraduate courses in biochemistry are provided.
Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition – toxic effects and benefits
- BiologyDrug metabolism reviews
This review covers the 22 (of the total of 57) human P450s in Families 5–51 and their substrate selectivity and update and discuss important aspects of each of these 22 P 450s and questions that remain open.
Cytochrome P450s and other enzymes in drug metabolism and toxicity
- Biology, ChemistryThe AAPS Journal
What fraction of drug toxicity actually involves metabolism, and how species and human interindividual variations affect pharmacokinetics and toxicity are considered are considered.
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems.
- Biology, ChemistryDalton transactions
An overview on recent progress and remaining problems in the CYP3A4 research is provided, which shows its extreme promiscuity in substrate specificity and cooperative substrate binding often leads to undesirable drug-drug interactions and toxic side effects.
Mechanisms of cytochrome P450 induction
- Biology, ChemistryJournal of biochemical and molecular toxicology
The mechanisms by which CYP3A4, 2B6, and 1A1 are induced involving the activation of the transcription factors pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor will be discussed.
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
- BiologyNature Reviews Cancer
A two-tiered system to predict an overall inter-individual risk of tumorigenesis based on DNA variants in certain 'early defence' CYP genes, combined with polymorphisms in various downstream target genes is suggested.
SHOWING 1-10 OF 70 REFERENCES
Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs.
- BiologyDrug metabolism and disposition: the biological fate of chemicals
Some recently developed bacterial systems that can be used for the production of metabolites, genotoxicity testing, and screening in random mutagenesis work are described.
Regulation of cyp3a gene transcription by the pregnane x receptor.
- Biology, ChemistryAnnual review of pharmacology and toxicology
The pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals and may prove useful in the treatment of diseases in which toxic metabolites accumulate, such as cholestatic liver disease.
Induction of cytochromes P450.
- BiologyCurrent drug metabolism
M mammals have evolved mechanisms to induce proteins involved in xenobiotic detoxification, andabolism by Phase I enzymes, particularly the heme containing monooxygenases cytochromes P450 is frequently the first line of defense against such xenobiotics.
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
- BiologyTrends in genetics : TIG
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
- Biology, ChemistryArchives of biochemistry and biophysics
Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review).
- Biology, ChemistryInternational journal of molecular medicine
The results suggest a role for CYP27A as a renal mitochondrial 1alpha-hydroxylase in the bioactivation of vitamin D3 under normal and pathological conditions and to discuss the results in relation to other published literature on these enzymes.
Xenobiotic-metabolizing Cytochromes P450 Convert Prostaglandin Endoperoxide to Hydroxyheptadecatrienoic Acid and the Mutagen, Malondialdehyde*
- Biology, ChemistryThe Journal of Biological Chemistry
The results suggest that co-expression of cyclooxygenase-2 and P450s in developing cancers may contribute to genomic instability due to production of the endogenous mutagen, MDA.
Cytochrome P450s: coupling development and environment.
- BiologyTrends in genetics : TIG
Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.
- BiologyMutation research