Clinical implications of shared genetics and pathogenesis in autoimmune diseases

@article{Zhernakova2013ClinicalIO,
  title={Clinical implications of shared genetics and pathogenesis in autoimmune diseases},
  author={Alexandra Zhernakova and Sebo Withoff and Cisca Wijmenga},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={646-659}
}
Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison disease and Hashimoto disease, originate as an autoimmune reaction that affects disease-specific target organs. These autoimmune diseases are characterized by the development of specific autoantibodies and by the presence of autoreactive T cells. They are caused by a complex genetic predisposition that is attributable to multiple genetic variants, each with a moderate-to-low effect size. Most of the genetic… Expand
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