Clinical implications of pharmacokinetics and pharmacodynamics of fluoroquinolones.

  title={Clinical implications of pharmacokinetics and pharmacodynamics of fluoroquinolones.},
  author={Brian Wispelwey},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={41 Suppl 2},
  • Brian Wispelwey
  • Published 2005 in
    Clinical infectious diseases : an official…
This review summarizes key data illustrating the clinical importance of pharmacodynamics, particularly among the fluoroquinolone family of antibacterials. Antibacterials are often divided into 2 groups--either time-dependent or concentration-dependent agents--on the basis of their mechanism of killing. Fluoroquinolones are concentration-dependent agents, and the parameter that correlates most closely with clinical and/or bacteriological success is the ratio of the area under plasma… CONTINUE READING