Clinical implications of neuroendocrine differentiation in prostate cancer

@article{Nelson2007ClinicalIO,
  title={Clinical implications of neuroendocrine differentiation in prostate cancer},
  author={E. Charles Nelson and Angelo J. Cambio and Joy Y. Yang and J-H Ok and Primo N. Lara and Christopher P Evans},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2007},
  volume={10},
  pages={6-14}
}
The cellular signaling pathways of the prostate play a central role in the induction, maintenance, and progression of prostate cancer (CaP). Neuroendocrine (NE) cells demonstrate attributes that suggest they are an integral part of these signaling cascades. We summarize what is known regarding NE cells in CaP focusing on NE cellular transdifferentiation. This significant event in CaP progression appears to be accelerated by androgen deprivation (AD) treatment. We examine biochemical pathways… CONTINUE READING
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