Clinical implications of PRAME gene expression in childhood acute myeloid leukemia.

@article{Steinbach2002ClinicalIO,
  title={Clinical implications of PRAME gene expression in childhood acute myeloid leukemia.},
  author={Daniel Steinbach and Johann Hermann and Susanne F Viehmann and Felix Zintl and Bernd Gruhn},
  journal={Cancer genetics and cytogenetics},
  year={2002},
  volume={133 2},
  pages={118-23}
}
The expression of the PRAME gene (preferentially expressed antigen of melanoma) was measured by quantitative reverse transcriptase polymerase chain reaction in 50 children with newly diagnosed acute myeloid leukemia (AML), three samples of CD34(+) stem cells, six bone marrow samples, and 10 peripheral blood samples of healthy donors, as well as three AML cell-lines (KG-1, U937, and HL-60). Eight patients were also analyzed in relapse. Contrary to previous reports, we could show that the PRAME… CONTINUE READING

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