Clinical implications of 2-hydroxydesipramine plasma concentrations.

  title={Clinical implications of 2-hydroxydesipramine plasma concentrations.},
  author={James C. Nelson and Jay L. Bock and Peter I. Jatlow},
  journal={Clinical pharmacology and therapeutics},
  volume={33 2},
The clinical utility of 2-hydroxydesipramine (2-OH-DMI) measurements was evaluated by examining the relationship of 2-OH-DMI concentrations in plasma to clinical outcome and side effects in depressed inpatients treated with desipramine (DMI). Studies were performed in responders and nonresponders to treatment and in patients experiencing subjective side effects or major adverse reactions necessitating interruption of treatment. Unlike DMI concentrations, 2-OH-DMI concentrations did not… CONTINUE READING

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