Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas.

@article{Fty1998ClinicalIO,
  title={Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas.},
  author={R{\'e}gine F{\'e}ty and Fr{\'e}d{\'e}ric Rolland and Muriel Barberi-Heyob and Agn{\`e}s Hardouin and Loic Campion and T Conroy and J. L. Merlin and Annalisa Rivi{\`e}re and Genevi{\`e}ve Perrocheau and M. C. Etienne and Giovanni Milano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 9},
  pages={2039-45}
}
A significant link between 5-fluorouracil (5FU) plasma concentration and its therapeutic activity has been demonstrated in colon and head and neck cancer patients for 5FU used as a continuous infusion. Dose adjustment based on pharmacokinetic follow-up has been proposed to decrease hematological and digestive toxicities, but the clinical impact of this approach has not yet been demonstrated. A randomized multicentric study was conducted to evaluate the clinical interest of 5FU dose adaptation… CONTINUE READING

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