Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model.

@article{Lynch1999ClinicalIO,
  title={Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model.},
  author={Henry T. Lynch and Patrice Watson and Trudy G. Shaw and Jane F. Lynch and Amy Harty and Barbara A. Franklin and C R Kapler and Susan T. Tinley and Bo Liu and Caryn Lerman},
  journal={Cancer},
  year={1999},
  volume={86 11 Suppl},
  pages={2457-63}
}
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of who has and who does not have inordinately increased susceptibility to CRC as well as a litany of extracolonic cancers. Mutation testing has focused on hMSH2 and hMLH1, the most common mutations in… CONTINUE READING

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