Clinical impact of early brain atrophy in clinically isolated syndromes.

  title={Clinical impact of early brain atrophy in clinically isolated syndromes.},
  author={Francisco Carlos P{\'e}rez-Miralles and Jaume Sastre-Garriga and Mar Tintore and Georgina Arrambide and Carlos Nos and H{\'e}ctor Perkal and Jordi R{\'i}o and Mari Carmen Edo and Alejandro Horga and Joaqu{\'i}n Castill{\'o} and C Auger and E Huerga and Alex Rovira and Xavier Montalban},
  journal={Multiple sclerosis},
  volume={19 14},
BACKGROUND The impact of global and tissue-specific brain atrophy on conversion to multiple sclerosis (MS) after a clinically isolated syndrome (CIS) is not fully gauged. OBJECTIVES We aimed to determine the magnitude and clinical relevance of brain volume dynamics in the first year after a CIS. METHODS We assessed 176 patients with CIS within 3 months of onset, clinically and by conventional magnetic resonance imaging (MRI) scans, at baseline and 1 year after clinical onset. We determined… CONTINUE READING
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