Clinical hurdles and possible solutions in the implementation of closed-loop control in type 1 diabetes mellitus.

@article{Zisser2011ClinicalHA,
  title={Clinical hurdles and possible solutions in the implementation of closed-loop control in type 1 diabetes mellitus.},
  author={Howard C. Zisser},
  journal={Journal of diabetes science and technology},
  year={2011},
  volume={5 5},
  pages={1283-6}
}
From an engineering perspective, controlling blood glucose appears to be a fairly straightforward single input (glucose), single output (insulin) control problem. Unfortunately, mimicking Mother Nature turns out to be a complex endeavor. The primary hurdle in developing a useful, safe closed-loop control algorithm for an artificial pancreas is the time delays associated with current continuous glucose monitors and subcutaneously delivered insulins. This article will provide a brief history of… CONTINUE READING

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