Clinical human hepatocyte transplantation: Current status and challenges.

  title={Clinical human hepatocyte transplantation: Current status and challenges.},
  author={Anil Dhawan},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  volume={21 Suppl 1},
1. Human hepatocyte transplantation (HT) has been shown to be of value in managing liver-based metabolic disorders; however, the cell function starts deteriorating after 1 year. 2. Human HT in alginate-embedded microbeads holds promise in the management of acute liver failure without the use of immunosuppression. 3. Challenges continue to be the availability of good quality hepatocytes, the monitoring of cell function, cryopreservation, and the immediate blood-mediated immune response leading… CONTINUE READING


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Maintenance of hepatic function in long-term in vitro co-culture with mesenchymal stem cells

Y Wu, RD Hughes, +3 authors A. Dhawan
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