Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells.

@article{Berg2009ClinicalgradeEV,
  title={Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells.},
  author={Maria L. Berg and Andreas Lundqvist and Philip McCoy and Leigh A Samsel and Yong Fan and Abdul Tawab and Richard Childs},
  journal={Cytotherapy},
  year={2009},
  volume={11 3},
  pages={341-55}
}
BACKGROUND AIMS Cancer immunotherapy involving natural killer (NK) cell infusions and administration of therapeutic agents modulating the susceptibility of tumors to NK-cell lysis has been proposed recently. We provide a method for expanding highly cytotoxic clinical-grade NK cells in vitro for adoptive transfer following bortezomib treatment in patients with advanced malignancies. METHODS NK cells were expanded with irradiated Epstein-Barr virus-transformed lymphoblastoid cells. Expanded… CONTINUE READING

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