Clinical features of sporadic and familial Alzheimer's disease.

Abstract

Alzheimer's disease is increasingly seen as an heterogeneous disorder with a variety of molecular pathologies converging on a final common pathway of abnormal amyloid deposition and tau phosphorylation. These result in the appearance of the senile plaques and neurofibrillary tangles and in the subsequent development of a cortical dementia with a prominent… (More)

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