Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.

@article{Coviello1997ClinicalFO,
  title={Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.},
  author={Domenico Coviello and Barry Joel Maron and P. Spirito and H. V. Watkins and Hans Peter Vosberg and Ludwig Thierfelder and Frederick J. Schoen and Jonathan G Seidman and Christine E Seidman},
  journal={Journal of the American College of Cardiology},
  year={1997},
  volume={29 3},
  pages={635-40}
}
OBJECTIVES We studied the clinical and genetic features of familial hypertrophic cardiomyopathy (FHC) caused by an Asp175Asn mutation in the alpha-tropomyosin gene in affected subjects from three unrelated families. BACKGROUND Correlation of genotype and phenotype has provided important information in FHC caused by beta-cardiac myosin and cardiac troponin T mutations. Comparable analyses of hypertrophic cardiomyopathy caused by alpha-tropomyosin mutations have been hampered by the rarity of… CONTINUE READING