[Clinical features of acute viral hepatitis A complicated with acute renal failure].


BACKGROUND Most patients with acute viral hepatitis A (AVHA) spontaneously recover, but a few patients experience complications. This study was carried out to examine clinical features of AVHA complicated with acute renal failure (ARF). METHOD Medical records of 404 patients with AVHA were reviewed. Clinical features of AVHA patients with ARF (group A) were compared with those of AVHA patients without ARF (group B). RESULT ARF complication was present in 11 patients (3%). There were no differences between group A and B in sex ratio and age. Microscopic hematuria (7 cases), proteinuria (7 cases), metabolic acidosis (4 cases), oliguria (4 cases), pulmonary edema (3 cases) and hyperkalemia (2 cases) were found in group A. The prevalence of heavy alcohol drinking (64% vs 3%, p<0.001) and diabetes mellitus (18% vs 1%, p=0.01) was higher in group A than B. The peak value of ALT (median: 4,290 IU/L vs 1,266 IU/L, p=0.006) and total bilirubin (median: 10.8 mg/dL vs 6.0 mg/dL, p=0.001) was higher in group A than B. Duration of admission was longer in group A than B (median: 14 days vs 5 days, p<0.001). Four patients of group A recovered with renal replacement therapy, while 7 patients recovered with conservative treatment. CONCLUSIONS The AVHA patients with ARF experienced more severe hepatitis than those without ARF, but they had a good prognosis with the proper treatment.

Cite this paper

@article{Song2007ClinicalFO, title={[Clinical features of acute viral hepatitis A complicated with acute renal failure].}, author={Kee Sup Song and Min Ju Kim and C. S. Jang and Hyuk Sang Jung and Hyun Hee Lee and Oh Sang Kwon and Yun soo Kim and Duck Joo Choi and Ju Hyun Kim and Seung Yeon Ha}, journal={The Korean journal of hepatology}, year={2007}, volume={13 2}, pages={166-73} }