Clinical features of Alzheimer’s disease

@article{Frstl1999ClinicalFO,
  title={Clinical features of Alzheimer’s disease},
  author={Hans F{\"o}rstl and Alexander Kurz},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={1999},
  volume={249},
  pages={288-290}
}
The preclinical stage of Alzheimer’s disease is inconspicuous and there are – almost by definition – no reliable and valid symptoms and signs which would allow a very early diagnosis before the manifestation of irreversible deficits. For a clinical diagnosis of dementia, cognitive impairment has to be severe enough to compromise the activities of daily living. In the mild dementia stage, difficulties with declarative memory are usually prominent; depressive symptoms are not infrequent, but the… CONTINUE READING
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