Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16‐year period

  title={Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16‐year period},
  author={D G Savage and Richard Szydlo and John M. Goldman},
  journal={British Journal of Haematology},
To determine major presenting features of chronic myeloid leukaemia (CML) in current practice, we have reviewed the records of 430 patients with CML referred to the Hammersmith Hospital for allogeneic bone marrow transplantation since 1981. Approximately 20% of cases were diagnosed incidentally. Symptoms such as fatigue and weight loss were associated with greater degrees of leucocytosis and splenomegaly and lower haemoglobin levels. Most bleeding patients had normal or elevated platelet counts… 
Clinical and Biological Features at Diagnosis in 40 Children With Chronic Myeloid Leukemia
It is shown that the characteristics of CML seem to differ in children compared with previously published adult series; in particular, the presenting leukocyte counts are often higher in children.
Clinical and Hematological Features of 335 Patients of Chronic Myelogenous Leukemia Diagnosed at Single Centre in Northern Pakistan
Anaemia and massive splenomegaly were the main clinical features found in 92% and 47% patients respectively, and there was significant correlation between anaemia and WBC counts with degree of splenomesgaly.
Forty-Seven Children Suffering from Chronic Myeloid Leukemia at a Center Over a 25-Year Period
The authors review 47 children under 18 years of age with CML who were admitted to the National Taiwan University Hospital in the period between 1976 and 2001 inclusively to determine the diagnostic characteristics, blast crisis status, appropriate treatment, overall patient survival, and prognostic factors pertaining to chronic myeloid leukemia for children.
Chronic myeloid leukaemia in central Africans.
The study has revealed that the presenting pattern of clinical and haematological features of CML is changing probably due to the advent of modern clinical practice coupled with increased physician density, greater awareness of disease among clinicians besides other reasons.
BCR/ABL-1-Positive Myeloproliferative Neoplasm Presenting with Isolated Remarkable Thrombocytosis with Atypical Clinicopathological Features: Discussion from Management Point of View
Upon literature review, it is found that there is no significant difference in disease prognosis in this group of patients compared to classic CML, provided TKI was started early in disease course.
An experience with sixty cases of haematological malignancies; a clinico haematological correlation.
In this study acute myeloid leukemia was the commonest type of haematological malignancy and males were affected more than the females.
Chronic myeloid leukaemia presenting with priapism as the only symptom: A case report and review of literature
High Index of Suspicion, as well as early full blood count and peripheral blood/Bone marrow examination among patients presenting with priapism will facilitate prompt and correct diagnosis, and reduce, if not prevent erectile dysfunction and other severe complications that may arise from priapist.
Presentating phases of chronic myeloid leukaemia.
CML presented at a younger age in the chronic phase, as determined by a study to determine the frequency of three phases of chronic myeloid leukaemia at first presentation.
The biology of chronic myelogenous leukemia in childhood and young adolescents: An indian perspective
This is one of the most recent reported series of CML in children and adolescents from India highlighting the difference in presentation from adults; mainly hepatomegaly, bleeding manifestations, and higher leukocyte count.
Clinical Features of CML
Despite the efficacy demonstrated with imatinib so far, resistance does occur and, in addition, sudden transformation to blast phase, particularly of lymphoid lineage, may occur and the outlook for patients with transformed disease remains poor even with intensive therapy including allogeneic transplantation.


The peripheral blood in chronic granulocytic leukaemia. Study of 50 untreated Philadelphia-positive cases.
Application of these findings should improve the accuracy of the haematological diagnosis of CGL, while study of the rare cases which possess the above features but are Ph1-negative may throw further light on the role of the Philadelphia chromosome in the natural history of C GL.
Thrombocytosis in chronic granulocytic leukemia: incidence and clinical significance.
The clinical significance of an elevated platelet count in the course of chronic in the group with counts over a 1 x 1 0’/cu granulocytic leukemia was studied and per se was associated with a shorter hospital stay.
Uncontrolled thrombocytosis in chronic myeloproliferative disorders
The thrombocytosis of myeloproliferative processes may pose a less serious threat than originally thought and that aggressive lowering of the platelet count may not be indicated in all cases.
Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation.
It should be possible to classify potential candidates for bone marrow transplantation according to risk with conventional therapy, and prognostic significance of disease features recorded at the time of diagnosis among 625 patients with Philadelphia chromosome-positive, nonblastic chronic granulocytic leukemia is examined.
Chronologic sequence in appearance of clinical and laboratory findings characteristic of chronic myelocytic leukemia.
The hypothesis that malignant transformation of Ph’-positive cells could develop in the early proliferative stage may contribute to elucidating the pathophysiology of blastic crisis of CML.
Chronic Leukemia: A Statistical Study of Symptoms, Duration of Life, and Prognosis1
The following analysis is based on 64 patients with myeloid and 64 with lymphatic leukemia treated by x-rays at the Presbyterian Hospital in New York between the years 1919 and 1939, inclusive.
Priapism complicating chronic granulocytic leukemia
Since 1952 we have seen nine patients with priapism leading to a diagnosis of chronic granulocytic leukemia (CGL) and a tenth patient who gave a history of priapism when CGL was diagnosed as a result
The chronic leukemias: a review of disease manifestations and the aims of therapy.
  • D. Bergsagel
  • Medicine, Biology
    Canadian Medical Association journal
  • 1967
Before therapy designed to eliminate the Ph(1)-positive (Philadelphia chromosome) stem cell is tried, it is needed to know whether a normal hematopoietic stem cell exists in Ph( 1)-positive CML.
Several cases of very early leukemia are described to describe several cases of chronic leukemia which have been studied and to review the available information concerning the course of this disease.
Polycythemia vera. A review of fifty cases with emphasis on the risk of surgery.
The clinical course, complications, and prognosis of polycythemia vera as exemplified by a group of 50 patients, with particular reference to the problem of surgical risk in this disorder is reviewed.