Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus

  title={Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus},
  author={K-Y. Yuen and Pks Chan and Malik Peiris and D. N. Tsang and T L Que and K. F. Shortridge and P. Cheung and Wk To and E W Ho and Rita Yn-Tz Sung and AF Cheng},
  journal={The Lancet},

Viral lung infections: Epidemiology, virology, clinical features, and management of avian influenza A(H7N9)

The emergence of A(H7N9) virus represents a significant health threat and high vigilance is necessary so that appropriate treatment can be instituted for the patient and preventive measures can be implemented.

Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China

The clinical course of Chinese H5N1 cases is characterized by fever and cough initially, with rapid progression to lower respiratory disease, and decreased platelet count, elevated LDH level, ARDS and cardiac failure were associated with fatal outcomes.

Avian influenza A (H5N1) in 10 patients in Vietnam.

Although in all 10 cases the infection appears to have been acquired directly from infected poultry, the potential exists for genetic reassortment with human influenzaviruses and the evolution of human-to-human transmission.

Avian influenza A (H5N1) infection in eastern Turkey in 2006.

H5N1, which causes a spectrum of illnesses in humans, including severe and fatal respiratory disease, can be difficult to diagnose.

Coronavirus as a possible cause of severe acute respiratory syndrome

Review of clinical symptoms and spectrum in humans with influenza A/H5N1 infection

Fever, cough and dyspnoea are the major symptoms on presentation, whereas gastrointestinal symptoms such as watery diarrhoea, vomiting and abdominal pain are common early in the course of the disease, and upper respiratory tract symptoms are less prominent in human H5N1 infection when compared to seasonal influenza.

A Detailed Epidemiological and Clinical Description of 6 Human Cases of Avian-Origin Influenza A (H7N9) Virus Infection in Shanghai

An outbreak of H7N9 infection occurred in the Minhang District of Shanghai that easily progressed to acute respiratory distress syndrome and indicated that human transmission may be involved in the spread of this infection.

Pathology of fatal human infection associated with avian influenza A H5N1 virus

It is postulated that in fatal human infections with this avian subtype, initial virus replication in the respiratory tract triggers hypercytokinemia complicated by the reactive hemophagocytic syndrome.



Influenza A viral infection associated with acute renal failure.

Influenza in Man

The clinical expression of infection with influenza virus is variable and is partially influenced by the nature of the infecting virus but to a greater extent is modulated by the age, physiological

Combination therapy with aerosolized ribavirin and intravenous immunoglobulin for respiratory syncytial virus disease in adult bone marrow transplant recipients.

It is concluded that RSV may cause devastating outbreaks of severe pneumonia among hospitalized adult BMT recipients and early diagnosis and combination therapy with ribavirin and IVIG was associated with a favorable outcome.

A pandemic warning?

An influenza A virus of the H5N1 subtype has now been identified in a human patient, raising discussions about its potential to spark a new human influenza pandemic.

Pandemic influenza: a zoonosis?

Evidence is presented that points strongly to pandemic influenza being a zoonosis, and consideration is given to the temporal and geographical factors and range of hosts, namely the duck, pig, and human, that need to be submitted to virus surveillance in China and beyond to attempt to anticipate a future pandemic.

Neurological and Hepatic Disorders Associated with Influenza

The clinical and pathological records and radiographs of 165 patients with pneumonia complicating influenza admitted to the 10 London undergraduate teaching hospitals in the autumn of 1957 are reviewed and the clinical assessment and emergency treatment of fulminating influenza are described.

Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses

A phylogenetic analysis of 52 published and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses indicates that these viruses have evolved independently since well before the first isolates in the early 1930s, and proposes that during 1918 a virulent strain of this new avianlike virus entered human or swine hosts.

Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients

It is demonstrated that rapid diagnosis of respiratory viral infections in children is a cost-effective procedure and significantly reduced hospital stays, antibiotic use, and laboratory utilization.

Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential.

Although the Pekin robin isolate did not produce disease in chickens under the conditions of the study it did have the amino acid sequence compatible with that in HP AI viruses and, therefore, is considered potentially HP.