Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.

@article{Shaw2009ClinicalFA,
  title={Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.},
  author={Alice Tsang Shaw and Beow Yong Yeap and Mari Mino-Kenudson and Subba R Digumarthy and Daniel Botelho Costa and Rebecca Suk Heist and Benjamin R Solomon and Hannah Stubbs and Sonal Admane and Ultan McDermott and Jeffrey Settleman and Susumu S Kobayashi and Eugene Jerome Mark and Scott J Rodig and Lucian R. Chirieac and Eunice Lee Kwak and Tom J. Lynch and Anthony John Iafrate},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 26},
  pages={4247-53}
}
PURPOSE The EML4-ALK fusion oncogene represents a novel molecular target in a small subset of non-small-cell lung cancers (NSCLC). To aid in identification and treatment of these patients, we examined the clinical characteristics and treatment outcomes of patients who had NSCLC with and without EML4-ALK. PATIENTS AND METHODS Patients with NSCLC were selected for genetic screening on the basis of two or more of the following characteristics: female sex, Asian ethnicity, never/light smoking… CONTINUE READING
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EML4ALK fusion is linked to histological characteristics in a subset of lung cancers

  • K Inamura, K Takeuchi, Y Togashi
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