Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations.

@article{Marchetti2011ClinicalFA,
  title={Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations.},
  author={Antonio Marchetti and Lara Felicioni and Sara Malatesta and Maria Grazia Sciarrotta and Luigi Guetti and Antonio Chella and Patrizia Viola and Carmela Pullara and Felice Mucilli and Fiamma Buttitta},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 26},
  pages={3574-9}
}
PURPOSE To investigate the prevalence, distribution, and prognostic role of BRAF mutations in a large cohort of white patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS A retrospective series of 1,046 NSCLCs-comprising 739 adenocarcinomas (ADCs) and 307 squamous cell carcinomas (SCCs)-was investigated for BRAF mutations. High-resolution melting analysis followed by sequencing and strip hybridization assay were used. All patients were also analyzed for KRAS and EGFR… CONTINUE READING
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